4/9/2023 0 Comments Olympus dss player license keyTTC9 was significantly associated with tumor immune infiltration patterns. The expression of TTC9 gene might be modulated by DNA copy number variant and DNA methylation. TTC9 might serve as oncogene in LUAD through cancer-related signaling pathways including p38 MAPK pathway. Moreover, inhibition of TTC9 suppressed the tumorigenicity of PC9 cells in nude mice. Subsequent cellular function assays demonstrated that knockdown of TTC9 promoted PC9 cell apoptosis and inhibited cell proliferation, migration and invasion, leading to cell cycle arrest in G2 phase. TTC9 expression was closely correlated with gender, lymph node metastasis, and survival status in the TCGA-LUAD cohort. TTC9 expression was significantly overexpressed in LUAD tissues compared with that in normal lung tissues. Here, we investigated the expression profiles, biological functions and potential molecular mechanism of the TTC9 gene in LUAD. However, the expression and role of TTC9 has not yet been elucidated in LUAD. Tetratricopeptide repeat domain 9A (TTC9) is upregulated and has played an oncogenic role in some malignant tumors. Lung adenocarcinoma (LUAD) is one of the most commonly diagnosed subtypes of lung cancer, and one of the deadliest cancers.
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